Bio-Organic Division is involved in focussed basic and applied research in bio-organic chemistry and biology of contemporary relevance. Directed research is oriented towards cancer targeting agents (radio-sensitizers, chemotherapeutic agents, phytomedicines and nuclear medicines) and other diseases (microbial infection and cardiovascular pathogenesis) in various in vitro and in-vivo models and exploratory organic materials research for application in nuclear fuel cycle and societal benefits.
Asymmetric total synthesis and organocatalytic methods (green chemistry approach) for the Synthesis of biologically active compounds.
Synthesis and development of cost- effective high value nuclear medicine ligands for diagnosis and therapy of cancer and other diseases
Design and synthesis of organo-fluorophores and organic electronic molecules, relevant to nuclear sciences and societal benefits (advanced technology and health).
Bio-rational phyto-chemistry for development of active principles from medicinal and dietary plants.
Various natural and modified drugs are evaluated for their potency to mitigate cardiovascular pathogenesis in different animal models hypertension, infarct and metabolic syndrome. To understand the mechanism behind the effects, various parameters are being checked to evaluate the potency which includes hypertension, cardiomyocte electrical conductions, infarct, heart rate variability, volume and pressure dynamic of heart and aorta, histological and biochemical evaluation among others
Understanding molecular processes for antibiotic resistance and development of natural product based antibiotics.
Understanding DNA damage repair, replication, redox biology and autophagy process and development of radio-sensitizers, chemo-sensitizers for cancer therapy.
Pharmacogenomics and synthetic lethality approach for development of natural drugs for cancer treatment.