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BARC


Mandate


Bio-Organic Division is involved in focussed basic and applied research in bio-organic chemistry and biology of contemporary relevance. Directed research is oriented towards cancer targeting agents (radio-sensitizers, chemotherapeutic agents, phytomedicines and nuclear medicines) and other diseases (microbial infection and cardiovascular pathogenesis) in various in vitro and in-vivo models and exploratory organic materials research for application in nuclear fuel cycle and societal benefits.


Highlights


11/2020

Repurposing of choloroquine, as an inexpensive adjuvant for breast cancer therapy



(8/2018) Asymmetric total synthesis and organocatalytic methods (green chemistry approach) for the Synthesis of biologically active compounds.


Asymmetric total synthesis and organocatalytic methods (green chemistry approach) for the Synthesis of biologically active compounds.



(8/2018) Synthesis and development of cost- effective high value nuclear medicine ligands for diagnosis and therapy of cancer and other diseases


Synthesis and development of cost- effective high value nuclear medicine ligands for diagnosis and therapy of cancer and other diseases



(8/2018) Design and synthesis of organo-fluorophores and organic electronic molecules, relevant to nuclear sciences and societal benefits (advanced technology and health).


Design and synthesis of organo-fluorophores and organic electronic molecules, relevant to nuclear sciences and societal benefits (advanced technology and health).



(8/2018) Bio-rational phyto-chemistry for development of active principles from medicinal and dietary plants.


Bio-rational phyto-chemistry for development of active principles from medicinal and dietary plants.



(8/2018) Cardio-vascular pathogenesis and its mitigation by natural and synthetic drugs.


Various natural and modified drugs are evaluated for their potency to mitigate cardiovascular pathogenesis in different animal models hypertension, infarct and metabolic syndrome. To understand the mechanism behind the effects, various parameters are being checked to evaluate the potency which includes hypertension, cardiomyocte electrical conductions, infarct, heart rate variability, volume and pressure dynamic of heart and aorta, histological and biochemical evaluation among others



(8/2018) Understanding molecular processes for antibiotic resistance and development of natural product based antibiotics.


Understanding molecular processes for antibiotic resistance and development of natural product based antibiotics.



(8/2018) Understanding DNA damage repair, replication, redox biology and autophagy process and development of radio-sensitizers, chemo-sensitizers for cancer therapy.


Understanding DNA damage repair, replication, redox biology and autophagy process and development of radio-sensitizers, chemo-sensitizers for cancer therapy.



(8/2018) Pharmacogenomics and synthetic lethality approach for development of natural drugs for cancer treatment.


Pharmacogenomics and synthetic lethality approach for development of natural drugs for cancer treatment.




Facilities

(12-11-2018) Animal arterial/ venous/ heart catheterization machine


This machine is used for catheterization of animal artery/ vein/ heart to analyse invasive systolic and diastolic blood pressure measurement. This is the gold standard for arterial and venous pressure measurement in rats/mice. This also gives a measure of the aortic notch/valve during aortic blood flow. This machine also gives the ventricular pressure dynamics both in systole and diastole and cardiac output of the animal heart.




Technologies Developed

(22-03-2018) SYNTHESIS OF LASER DYE PM597 [CH17LPTDBOD].




(22-03-2018) SYNTHESIS OF LASER DYE PM567 [CH17LPTDBOD].





Show Cases

BARC

BOD: Application oriented products

BARC

BOD: Products with therapeutic values

BARC

Antifibrotic and antiarrhythmic acticity of Malabaricone C

BARC

Non-Invasive blood pressure and ECG analysing machine for rats

23-Feb-2021