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BARC


Mandate

The focus of research at RB&HSD is in the frontier areas of radiation biology for understanding the effect of low- and high LET radiations, chronic and acute radiation exposure, high background radiation, and radionuclide exposure on mammalian cells, cancer cells, experimental rodents and human health.
Preclinical and translational research is aimed at development of new drugs and therapeutics for prevention and mitigation of radiation injury, de-corporation of heavy metals and treatment of inflammatory disorders and cancers.
We are also studying macromolecular structures and protein-ligand interactions using biophysical techniques like X-ray crystallography, neutron-scattering, circular dichroism and synchrotron radiation, with an aim for ab initio design of therapeutic molecules.


Facilities

(01-12-2020) Plasma Irradiation System


With Dr. Anu Ghosh



(03-11-2020) Protein production and chracterization


With Dr. Mukesh Kumar



(03-11-2020) X-ray diffractometer


With Dr. Mukesh Kumar



(03-11-2020) Protein Crystallization


With Dr. Mukesh Kumar



(03-11-2020) In-vivo photon imaging system


With Dr. B. N. Pandey



(03-11-2020) Alpha and gamma irradiator


With Dr. B. N. Pandey



(03-11-2020) ELISPOT Reader


With Dr. Bhavani Shankar



(03-11-2020) Hypoxia Chamber


With Dr. S. Santosh Kumar & Dr. B. N. Pandey



(03-11-2020) Fluorescence Microscope


With Dr. S. Santosh Kumar, Dr. B. N. Pandey & Dr. Bhavani Shankar



(03-11-2020) Confocal Microscope


With Dr. S. Santosh Kumar & Dr. B. N. Pandey



(03-11-2020) HPLC


With Dr. S. Santosh Kumar



(03-11-2020) Flow Cytometer


With Dr. S. Santosh Kumar and Dr. Bhavani Shankar



(03-11-2020) Cell Sorter


With Dr. S. Santosh Kumar



(03-11-2020) Highthroughput Cell Analyzer


With Dr. S. Santosh Kumar



(03-11-2020) Blood Irradiator


With Dr. B. N. Pandey



(03-11-2020) Bhabhatron


With Dr. B. N. Pandey




Technologies Developed

(31-12-2020) India's First Indigenous Alpha Irradiator




(31-03-2017) Bio-Engineering of Lectin Based Radioprotector


The technology on “Bio-Engineering of Lectin Based Radioprotector” was incubated with M/S Gennova Biopharmaceutics, Pune on 31st March, 2017 for manufacturing of BRP based therapeutic formulation and its new variants under GMP conditions and conducting clinical trials.



(10-07-2015) Development of Radioprotector Drug Formulation


Technology on “Development of Radioprotector Drug Formulation” was incubated with M/S IDRS Labs Pvt Ltd, Bengaluru on 10th July 2015 for making tablets of BRM under GMP conditions. This MoU was extended in Feb 2017 for conducting clinical trials.




Show Cases

BARC

Development of novel therapeutics for mitigation of radiation toxicity, cancer and immune disorders

BARC

High level area of Kerala coast

BARC

Animal House Facility

BARC

Protein crystallography research for understanding biology at molecular level

BARC

Understanding tumor immune interaction for development of novel cancer therapeutics

BARC

Understanding radiation induced bystander effects and biological effects of Th-232

BARC

Biological and molecular effects of ionizing radiation

30-Mar-2022