OncoDiagnoScope is a tablet computer based, compact and portable health-care instrument for real-time screening/ diagnosis of oral cavity cancer. A touch-screen enabled graphic user interface (GUI) software provides the necessary interface for the hardware control of the instrument and automation of data acquisition and analyses. During carcinogenesis, the optical properties of oral mucosa are altered. These optical changes can be measured with this USB powered machine using a pencil-sized stainless steel fiber optic probe. The fiber optic probe is brought in contact with the suspected tissue of the oral cavity of a patient and light is shone upon it. The light coming out of the tissue is captured and fed to the tablet computer where it is analyzed by a smart algorithm which can instantly determine whether the tissue is cancerous or not. The device has been validated on patients with oral neoplasia in various hospitals and cancer screening camps and found to detect cancer with an accuracy of over 90%.
Oral cancer is one of the most common cancers in India and its incidence is on a rise due to consumption of tobacco and pan masala. Presently, the only definitive method for determining oral cancer is through histopathological evaluation of the biopsied tissue from the suspected site. Biopsy is invasive, subject to random sampling errors and is, therefore, not an ideal screening tool. Optical spectroscopy has been suggested and validated as a powerful alternate tool for non-invasive screening of oral cancers.
The developed device is a compact and portable, optical spectroscopy based, health-care instrument intended for real-time diagnosis/screening of oral cavity cancer. With the assistance of this instrument, doctors will be able to non-invasively detect, in real-time, whether any pre-cancerous or cancerous lesion is present in the oral cavity of the subject he is examining. It uses two types of light (fluorescence and reflectance) returned from the tissue to determine its' tissue type without disturbing or destroying the tissue. The device has been validated on patients with oral neoplasia in various hospitals and cancer screening camps and found to detect cancer with an accuracy of over 90%.
The Laser Biomedical Applications Section at Raja Ramanna Centre for Advanced Technology, Indore, a unit of department of Atomic Energy has developed a tablet computer based, compact and portable health-care instrument, called OncoDiagnoScope, for in-vivo screening/ diagnosis of oral cavity cancer. The system consists of light emitting diodes (LEDs) and a chip-based miniaturized fiber-optic spectrometer all accommodated in a rectangular acrylic house and SMA connected to a custom-designed, pencil-sized stainless steel fiber optic probe having three legs each comprising a fused silica fiber. A miniaturized electronic data acquisition card mounted on the base of the house powers up the LEDs and is interfaced with the tablet computer fitted on the top of the acrylic house through its USB ports. A touch-screen enabled graphic user interface (GUI) software provides the necessary interface for the hardware control of the whole system and automation of data acquisition and data analysis. To measure the optical signals the fiber optic probe is brought in contact with the suspected tissue of the oral cavity of a patient. The light coming out of the tissue is captured and fed to the tablet computer where it is analyzed by a smart diagnostic algorithm which can instantly determine whether the tissue is cancerous or not. The algorithm also generates the posterior probability of diagnosis of the interrogated tissue site. Based on the probability output that the algorithm provides, red, green or orange flash is displayed with red and green implying confirmed (probability >cutoff decided by the physician) abnormal and normal respectively, while the orange indicating doubtful. The entire investigation procedure per subject using this device is less than 15 minutes as compared to several hours required by the conventional procedure of biopsy followed by histopthaology. Using this device, oral lesions can be accurately separated in a non-invasive manner from healthy oral tissues based on their natural characteristics in response to light. The device has been validated on patients with oral neoplasia in various hospitals and cancer screening camps and found to detect cancer with an accuracy of over 90%.
SPECIFICATIONS OF THE SYSTEM
| Sr. No. | Specification | Value |
|---|---|---|
| Main Unit | ||
| 1 | Mechanical Dimensions | 16 cm X 12cm X 8.5cm |
| 2 | Weight | 2.5 Kg |
| 3 | Power Input | Device draws power from USB |
| Fiber Optic probe | ||
| 4 | Fiber configuration | Permanently-aligned combination of three (two excitation and one collection) fused-silica single optical fibers (600 core diameter, N.A. 0.22). The fibers running through three different legs will meet at a junction 300mm away from the distal ends of the fiber and will run through a single leg till the probe head |
| 5 | Wavelength range | 300-1000 nm |
| 6 | Probe Connectors | Standard SMA (premium-grade SMA905 connectors) termination at both the excitation and the collection fiber(s) ends. |
| 7 | Probe end | Fiber-optic cylindrical probe head (diameter 5 ± 0.5 mm, length 200 ± 5 mm) enclosed in stainless steel body fitted with a quartz flat of thickness 2 ± 0.2 mm at the tip |
| 8 | Tubing | Properly jacketed to resist damage via physical shock |
| 9 | Cable length | 2 meter |
INFRASTRUCTURE
Test Equipments
Skilled Manpower
POWER
