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A Rapid, Continuous and Renewable Method for
Production of the Anti-Cancer Drug Camptothecin
  • Overview
  • Quick View Leaflet
  • Detail Technical Brochure
  • Application Procedure

A Rapid, Continuous and Renewable Method for Production of the Anti-Cancer Drug Camptothecin

 

 

Overview

BARC has developed a biotechnological approach for the production of the high value anticancer drug Camptothecin. Using this protocol, plants may also be propagated and utilized for the production of bioactive compounds. Thus, this is useful for the conservation and preservation of elite medicinal plants producing pharmaceutically important compounds. The method is continuous and products are obtained during a short period of time.

Anticancer drug Camptothecin

Anticancer drug Camptothecin
Quick View Leaflet

 ADVANTAGES

  • The method is reproducible

  • High levels of camptothecin can be obtained during a short period of time

  • Plant in nature, survive only for 8-9 months whereas the present technology represents a continuous and a reproducible method for camptothecin production

Medicinal plants form an important source for a wide variety of natural products used in the treatment of a various types of diseases like cancer, hypertension, malaria, AIDS etc. These drugs possess a complex organic structure with several chiral centres and are difficult to synthesise in the laboratory. On the contrary , plants accumulate these products with ease under natural conditions. This in turn has resulted in the exploitation of several medicinal plants for the production and export of life saving drugs. In the case of the anticancer drug camptothecin, commercial production is from the tree Camptotheca acuminata. Many trees are uprooted from the natural flora and used for camptothecin production. Biotechnological approaches on the medicinal plant Ophiorrhiza. developed in BARC showed significant levels of camptothecin during a short period of time. Thus they provide a continuous and renewable source for the production of the high value drug camptothecin.

APPLICATION AREAS

  • The method is useful to multiply elite medicinal plants which inturn help in the conservation and preservation of endangered medicinal plants that are becoming rare and extinct in the natural habitat due to overexploitation

  • This technology can be taken up by biotech and pharmaceutical companies already engaged in medicinal plant based research

A Rapid, Continuous and Renewable Method for Production of the Anti-Cancer Drug Camptothecin
Detail Technical Brochure

Medicinal plants form an important source for a wide variety of natural products used in the treatment of a various types of diseases like cancer, hypertension, malaria, AIDS etc. These drugs possess a complex organic structure with several chiral centres and are difficult to synthesise in the laboratory. On the contrary , plants accumulate these products with ease under natural conditions. This in turn has resulted in the exploitation of several medicinal plants for the production and export of life saving drugs. In the case of the anticancer drug camptothecin, commercial production is from the tree Camptotheca acuminata. Many trees are uprooted from the natural flora and used for camptothecin production. Biotechnological approaches on the medicinal plant Ophiorrhiza. developed in BARC showed significant levels of camptothecin during a short period of time. Thus they provide a continuous and renewable source for the production of the high value drug camptothecin.

Anticancer drug Camptothecin

ADVANTAGES

  • The method is reproducible
  • High levels of camptothecin can be obtained during a short period of time
  • Plant in nature, survive only for 8-9 months whereas the present technology represents a continuous and a reproducible method for camptothecin production

APPLICATION AREAS

  • The method is useful to multiply elite medicinal plants which inturn help in the conservation and preservation of endangered medicinal plants that are becoming rare and extinct in the natural habitat due to overexploitation
  • This technology can be taken up by biotech and pharmaceutical companies already engaged in medicinal plant based research

REQUIREMENTS

a. Infra structure

  • A tissue culture laboratory , a chemistry laboratory with facilities for drying plant material, solvent extractions, evaporation and estimation of products

b. Raw Materials

  • Chemicals required for tissue culture and chemical analysis are available locally

c. Equipment

  • Standard glassware for media preparation and sterilization equipment like autoclave, sterile bench, growth room etc., TLC plates for separation of compounds and HPLC for quantification of the products may be required

d. Man power

  • One botanist, one chemist and 1-2 technical assistants would be adequate for this purpose

Who Should apply


Interested parties with Engineering & Scientific knowledge, good financial background and adequate experience of products manufacturing & fabrication with technical capability in the area of interested technology and having or interested in setting –up facilities for production would be preferred.


How to apply

Send your Technology Transfer Application form duly filled and signed alongwith a Demand Draft/Bankers cheque of Rs. 500/- (for Indian entities) or US $50/- (for foreign entities) drawn in favour of “Accounts Officer, BARC” as application processing fee on following address: 

Head, Technology Transfer and Collaboration Division 
Bhabha Atomic Research Centre,
Trombay, Mumbai – 400 085, India.

Fax : +91-22-25505151


Note:Applications without processing fee as applicable above of Rs. 500/- or US $50/- for each technology will not be considered.


Click here for Technology Transfer Application Form

Contact Us

Head, 
Technology Transfer and Collaboration Division
Bhabha Atomic Research Centre,
Trombay, Mumbai 400 085.

Fax : 091-022- 25505151
Email : technology@barc.gov.in

How to apply

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