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Nitrogen Oxides Releasing Wound Dressing
  • Overview
  • Quick View Leaflet
  • Detail Technical Brochure
  • Application Procedure
Nitrogen Oxides Releasing Wound Dressing
Overview

The nitrogen oxides releasing wound dressing is useful for the treatment of chronic infected wounds and non- healing wounds (diabetic foot, pressure ulcer, venous stasis wound etc). The dressing works by decreasing the infection, increasing the microvascularization and granulation thereby aiding wound healing. The dressing is also suitable for application which requires preparation of wound bed for acceptance of split skin graft based surgery. The dressing is poly-antimicrobial (antibacterial and antifungal) activity including antibiofilm and is capable of sustained release of the active ingredient over a long period of time. The dressing is simple in preparation, low in cost and it can be stored at ambient temperature and humidity for two years, without loss of activity.

Nitrogen Oxides Releasing Wound Dressing

  

 

Quick View Leaflet

An injury to the skin leads activation of a signaling cascade which produces nitric oxide as a signaling molecule, which in turn leads to angiogenesis proliferation and collagen deposition in the damaged wound area. Nitric oxide also plays a very crucial role in fighting the infection. Delay in healing process is essentially due to local infection (105 colony counts/ g of tissue), Trauma, Foreign bodies, Malnutrition, Diabetes, Medication, Immunodeficiency. Unfortunately people who suffer from diabetes, or those who are elderly often do not produce enough nitric oxide naturally which can lead to poor wound healing. The Nitrogen oxides (primarily contains Nitric oxide, NO) releasing wound dressing is useful for the treatment of such chronic wounds. The dressing shows excellent poly-antimicrobial (antibacterial and antifungal) activity, including antibiofilm activity and is capable of sustained release of the active ingredient over long period of time.

ADVANTAGES

  • The dressing is suitable for application on infected, non-healing wounds

  • The dressing can be stored at ambient temperature and humidity conditions for two years, without loss of activity

  • The dressing is relatively inexpensive, broad-spectrum in action and the drug active molecule does not lead to resistance development


APPLICATIONS

  • The dressing is useful for treatment of chronic infected wounds and non- healing wounds (diabetic foot, pressure ulcer, venous stasis wound etc)

  • The application of this dressing on wounds especially in diabetic patients can lead to decrease in the infection, increase in microvascularization and granulation thereby, leading to faster wound healing

  • The dressing is also suitable for applications which require preparation of wound bed for acceptance of split skin graft based surgery

Nitrogen Oxides Releasing Wound Dressing
Detail Technical Brochure

An injury to the skin leads activation of a signaling cascade which produces nitric oxide as a signaling molecule, which in turn leads to angiogenesis proliferation and collagen deposition in the damaged wound area. Nitric oxide also plays a very crucial role in fighting the infection. The delay in wound healing process is essentially due to local infection (105 colony counts/ g of tissue), Trauma, Foreign bodies, Malnutrition, Diabetes, Medication, Immunodeficiency. Unfortunately people who suffer from diabetes, or those who are elderly often don’t produce enough nitric oxide naturally which can lead to poor wound healing. The nitrogen oxides releasing wound dressing is useful for the treatment of such chronic wounds. The dressing has shown excellent poly-antimicrobial (antibacterial and antifungal) activity, including antibiofilm activity and is capable of sustained release of the active ingredient over long period of time.

Working Principle of Dressing

The dressing works on the antimicrobial properties of Nitrogen oxides (NOx; the main component being nitric oxide). The dressing promotes angiogenesis, which helps in the graft acceptance to the wound bed. The NOx(g) released is be able to penetrate through the exopolysaccharide matrix of the biofilms in the wounds causing infection. Nitric oxide additionally has wound healing property thereby, aiding faster wound closure.
The dressing also contains collagen, a protein that gives the skin its tensile strength and plays a key role in wound healing. It attracts cells such as fibroblasts and keratinocytes to the wound, encourages angiogenesis and re-epithelialization. In addition, collagen provides a natural scaffold or substrate for new tissue growth.

Working Principle of Dressing

Applications

  • The dressing is useful for treatment of chronic infected wounds and non-healing wounds (diabetic foot, pressure ulcer, venous stasis wound etc)
  • The application of this dressing on wounds especially in diabetic patients leads to control of biofilm, increased microvascularization and granulation thereby, leading to faster wound healing
  • The dressing is also suitable for applications which requires preparation of wound bed for acceptance of split skin graft based surgery

Advantages

  • The product is suitable for application on infected or non-healing wounds
  • The dressing can be stored at ambient temperature and humidity conditions for up to two years, without loss of activity
  • The dressing is easy to manufacture, relatively inexpensive, broad-spectrum in action and the active drug molecule does not lead to resistance development

Raw materials

  • The raw materials are easily available in local market

Infrastructure

  • A Chemical Laboratory having fume hood, Basic microbiology laboratory set-up, Access to Gamma chamber for irradiation, Hot air oven, Sonicating bath, UV source & Freeze-drier or any other alterative equipment are required

Manpower

  • One trained person having degree in Chemistry & One person having degree in Microbiology with two semi-skilled workers would be adequate for production of nitrogen oxides releasing wound dressing

 

Who Should apply


Interested parties with Engineering & Scientific knowledge, good financial background and adequate experience of products manufacturing & fabrication with technical capability in the area of interested technology and having or interested in setting –up facilities for production would be preferred.


How to apply

Send your Technology Transfer Application form duly filled and signed alongwith a Demand Draft/Bankers cheque of Rs. 500/- (for Indian entities) or US $50/- (for foreign entities) drawn in favour of “Accounts Officer, BARC” as application processing fee on following address: 

Head, Technology Transfer and Collaboration Division 
Bhabha Atomic Research Centre,
Trombay, Mumbai – 400 085, India.

Fax : +91-22-25505151


Note:Applications without processing fee as applicable above of Rs. 500/- or US $50/- for each technology will not be considered.


Click here for Technology Transfer Application Form

Contact Us

Head, 
Technology Transfer and Collaboration Division
Bhabha Atomic Research Centre,
Trombay, Mumbai 400 085.

Fax : 091-022- 25505151
Email : technology@barc.gov.in

How to apply

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